Some Hollywood stars who want the effects of Botox but who want to use a more "natural" method of treatment, have started using the venom from the bite of the yellow crazy ant (Anoplolepis gracilipes) as an alternative. The major downside to this alternative treatment is a temporary boil that appears at the site of the injection and last between 5 to 7 days. After that the wrinkle-smoothing properties are almost identical in degree and duration to Botox.